Engineering altered protein–DNA recognition specificity

Object recognition: view-specificity and motion-specificity

This paper describes an experiment to distinguish between two theories of human visual object recognition. According to the view-specificity hypothesis, object recognition is based on particular learned views, whereas the motion-specificity hypothesis states that object recognition depends on particular directed view-sequences. Both hypotheses imply a degree of view-bias (i.e. recognition of a ...

Bleomycin congeners exhibiting altered DNA cleavage specificity.

Sir: The bleomycins (BLM’s) are a family of structurally complex glycoprotein antibiotics possessing significant anticancer activity ( I ) . They have been demonstrated to effect DNA strand scission in a reaction that is both metal ion and oxygen dependent (2); this transformation is believed to form the basis for the therapeutic efficacy of the bleomycins. A number of studies have demonstrated...

The Immunological Specificity of Chemically Altered Proteins

The serological properties of iodoproteins prepared by a method which involves less drastic treatment of the protein than the methods previously used for this purpose confirm the findings of Obermayer and Pick (1) and later authors, that iodination of proteins results in a more or less complete loss of species specificity and that a new specificity characteristic for iodoproteins is produced. A...

Combinatorial Engineering of Dextransucrase Specificity

We used combinatorial engineering to investigate the relationships between structure and linkage specificity of the dextransucrase DSR-S from Leuconostoc mesenteroides NRRL B-512F, and to generate variants with altered specificity. Sequence and structural analysis of glycoside-hydrolase family 70 enzymes led to eight amino acids (D306, F353, N404, W440, D460, H463, T464 and S512) being targeted...

Differential Recognition of Altered Peptide